Domineering Nonautonomy Mathematical Modeling of Planar Cell Polarity
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منابع مشابه
Mathematical modeling of planar cell polarity to understand domineering nonautonomy.
Planar cell polarity (PCP) signaling generates subcellular asymmetry along an axis orthogonal to the epithelial apical-basal axis. Through a poorly understood mechanism, cell clones that have mutations in some PCP signaling components, including some, but not all, alleles of the receptor frizzled, cause polarity disruptions of neighboring wild-type cells, a phenomenon referred to as domineering...
متن کاملVan Gogh: a new Drosophila tissue polarity gene.
Mutations in the Van Gogh gene result in the altered polarity of adult Drosophila cuticular structures. On the wing, Van Gogh mutations cause an altered polarity pattern that is typical of mutations that inactivate the frizzled signaling/signal transduction pathway. The phenotype however, differs from those seen previously, as the number of wing cells forming more than one hair is intermediate ...
متن کاملSupporting Online Material for “Mathematical modeling of planar cell polarity to understand domineering non-autonomy”
Supporting Text . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 The Factor X or Z model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Mathematical model formulation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Numerical methods . . . . . . ...
متن کاملMutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling.
The adult cuticular wing of Drosophila is covered by an array of distally pointing hairs that reveals the planar polarity of the wing. We report here that mutations in dachsous disrupt this regular pattern, and do so by affecting frizzled signaling. dachsous encodes a large membrane protein that contains many cadherin domains and dachsous mutations cause deformed body parts. We found that mutat...
متن کاملThe function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy.
The Drosophila epidermis is characterized by a dramatic planar or tissue polarity. The frizzled pathway has been shown to be a key regulator of planar polarity for hairs on the wing, ommatidia in the eye, and sensory bristles on the notum. We have investigated the genetic relationships between putative frizzled pathway downstream genes inturned, fuzzy, and multiple wing hairs (inturned-like gen...
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